Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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benzhydrocodone/acetaminophen and pentobarbital both boost sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom alternative remedy selections are insufficient
Pattern forming: Barbiturates may very well be habit forming. Tolerance, psychological and physical dependence may well occur with ongoing use. (See “Drug Abuse and Dependence” and “Pharmacokinetics” sections.) Patients that have psychological dependence on barbiturates may possibly improve the dosage or lessen the dosage interval without consulting a medical professional and could subsequently establish a Actual physical dependence on barbiturates. To reduce the potential for overdosage or the development of dependence, the prescribing and dispensing of sedative-hypnotic barbiturates needs to be limited to the quantity expected to the interval until eventually the subsequent appointment.
Keep an eye on Carefully (1)pentobarbital will decrease the extent or effect of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Keep an eye on individuals already on buprenorphine subdermal implant who require freshly-initiated remedy with CYP3A4 inducer for signals and symptoms of withdrawal. Should the dose with the concomitant CYP3A4 inducer cannot be lessened or discontinued, implant elimination might be vital plus the patient really should then be handled with a buprenorphine dosage variety that permits dose adjustments.
pentobarbital will reduce the level or effect of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
pentobarbital will reduce the extent or effect of siponimod by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of siponimod with a drug that causes reasonable CYP2C9 plus a moderate or sturdy CYP3A4 inducer isn't advisable.
pentobarbital will decrease the extent or effect of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lower in fentanyl plasma concentrations, insufficient efficacy or, perhaps, advancement of the withdrawal syndrome in a patient who more info may have formulated physical dependence to fentanyl.
pentobarbital will decrease the level or effect of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Sturdy or reasonable CYP3A4 inducers may well improve amount of diazepam elimination; consequently, efficacy of diazepam may very well be reduced.
pentobarbital will minimize the level or effect of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will lower the extent or effect of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
pentobarbital will lower the level or effect of loratadine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will reduce the level or effect of piroxicam by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Importance Mysterious.
pentobarbital will reduce the level or effect of mifepristone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers have not been researched, coadministration not encouraged by company
pentobarbital will reduce the extent or effect of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Strong or reasonable CYP3A4 inducers might maximize fee of diazepam elimination; consequently, efficacy of diazepam may be diminished.
pentobarbital will lower the extent or effect of eucalyptus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known.